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The difference between Vinifera and Hybrid? The Vitis vinifera is the European species of grape most commonly used for wine production. French Hybrids were developed in France in the late 19th and early 20th centuries by crossing hardy North American varieties with European vinifera varieties with the goal being to have pest and disease resistant grapes with the wine quality of vinifera grapes. Vinifera cultivars have been planted in Nova Scotia since the 1980’s, however, extreme winter temperatures have affected the success rates.